BioSkryb Genomics  

ResolveDNA™ Whole Genome Amplification Kits overcome the inherent challenges of low coverage uniformity in single-cell genomics that lead to increased sequencing costs and complex data analysis.

The controlled reaction parameters employed in this PTA-based kit enables reproducible recovery of >95% of the genomes of single cells and limited DNA input samples with industry-leading uniformity and accuracy.

Key features and benefits of ResolveDNA Whole Genome Amplification Kits include:

• *Significantly lower allelic dropout and biases compared to existing WGA methods that yield low and variable coverage across the genome
• *Specific amplification of the primary template with >97% of reads mapping to the human genome and no detectable product in no template control reactions
• *Simple, user-friendly workflow that requires less than 45 mins of hands-on time
• *Consistent WGA fragment sizes and yields from picogram to nanogram inputs

ResolveOME™ Key Highlights:

• Complete genome and full-length mRNA coverage reveals the consequence of genomic variation (all major variant classes) on gene expression and transcript structure, and exposes subtle changes in protein sequence that may profoundly impact structure, function, and activity.

• A unified workflow for the interrogation of DNA and RNA from the same cell obviates the need for splitting source material or interpret across data sets.

• Full transcriptome workflow enables enhanced RNA analysis compared to droplet-based single-cell RNA sequencing, providing full transcript RNA-Seq, splicing and isoform detection, and gene fusion detection.