At a time when diabetes and other sugar-related health problems are on the rise, many are turning away from sugar-loaded diets to sweeteners that are missing that delicious sugary satisfaction. Purecane, a zero-calorie all-natural sugar substitute made from sugarcane, was created by Amyris using precision fermentation. Its hero ingredient is Sugarcane Reb M, an extremely rare and pure molecule that tastes most like sugar and has no bitter aftertaste.