Near-infrared Analysis: What Is Unique About This Analytical Technique and What Challenges Remain To Make it Even Better?
Wednesday, March 10, 2021: 11:05 AM - 11:25 AM
Modern near-infrared analysis is approaching its 56th birthday, since Karl Norris and Joe Hart measured the “spectral absorbance curve for a thin layer of ground wheat for the 1.0- to 2.3-μ region, showing that the 1.94-μ band of water has a minimum of interference.” Since those early measurements, the application of this analytical technique has advanced rapidly and today is used globally for quality control in most agricultural and manufactured products during production. One challenge still not fully solved for near-infrared instrumentation is the seamless transfer of methods or calibrations from one instrument to another. A variation of this challenge is the creation of a technology that provides long-term instrument stability that allows continuous use of multivariate calibrations over time without periodic recalibration or calibration adjustment work. The technical issues associated with multivariate calibration transfer for spectroscopic instruments using absorption spectroscopy have been studied and reported for some time. Calibration transfer refers to a combination of instrument technology and chemometric techniques that are used to attempt to apply a single spectral database, and the calibration model developed using that database, for two or more instruments, with retained accuracy and precision. There are many technical aspects involved in successful calibration transfer, related to the measuring instrument reproducibility and repeatability, the reference chemical values used for the calibration, the multivariate mathematics used for calibration, and so forth. Ideally a multivariate model developed on a single instrument would provide a statistically identical analysis when used on the same instrument or other instruments following transfer. What challenges remain and what are the potential solutions to these challenges?
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