Welcome to your Pittcon 2021 Exhibitor Console!
The Exhibitor Console is your hub for all the information you need to know about exhibiting at Pittcon 2021!
Time-gated Imaging and Drug Delivery with Self-destructing, Self-targeting Porous Silicon Nanoparticles
Monday, March 08, 2021: 9:40 AM - 10:15 AM
Speaker(s)
Description
This presentation aims to describe design features needed for nanoscale vehicles to achieve effective targeting to, and imaging of diseased tissues in vivo. Nanophase silicon is one of the few semiconductor "quantum dot" materials that is non-toxic and that degrades to non-toxic byproducts. For self-reporting drug delivery applications, advantages include the tissue-penetrating near-infrared wavelength of emission and the long-lived (microseconds) excited state lifetime. Here we will emphasize siRNA-mediated gene silencing agents, using a photoluminescent porous silicon nanoparticle delivery system. We break the problem into three elements: (1) condenser chemistries to maximize loading of nucleic acid therapeutics while preserving intrinsic photoluminescence; (2) protection of the biologic payload from degradation and clearance; and (3) release of the biologic payload with the correct spatial and temporal concentration profile to maximize efficacy.
Additional Info
Keywords: Please select up to 4 keywords ONLY:
Biotechnology,Biomedical Engineering,Nanoscience
For Technical Support with this webpage, please contact support.