Octadecyl silica (ODS) is the industry standard column packing material for high performance liquid chromatography (HPLC). However, ODS as a packing material has two limitations: peak tailing of basic compounds due to residual silanol moieties, and poor hydrolytic stability against alkaline mobile phases. For efficient analysis of basic drugs, the... Read More

• Oral Abstract

Industrial hemp is a plant of the genus Cannabis, which contains no more than 0.3% delta-9 tetrahydrocannabinol (THC) on a dry weight basis in any part of the plant (e.g., leaves, flowers, and stems), whether growing or not. Total THC concentration is typically monitored using liquid chromatography (LC) to determine... Read More

• Oral Abstract

Two-Dimensional Liquid Chromatography (2D-LC) now makes separation and analysis of very complex mixtures achievable by improving peak capacity and selectivity dramatically. Despite being such a powerful chromatographic tool, 2D-LC technology can often be seen as a “promising toy,” that in its current state, unleashes a series of arduous method development... Read More

• Oral Abstract

Liquid chromatography (LC) is a widely used analytical tool for the separation of analytes in complex mixtures. Previous work demonstrated that continuous gradient stationary phases (C18, and phenyl) can be employed to improve the selectivity of a separation. These gradient stationary phases show a gradual decrease in ligand density along... Read More

• Oral Abstract

Stationary phase gradients are an emerging area of separation optimization in liquid chromatography (LC). Continuous stationary phase gradients, in which ligand density varies gradually within a single column, have demonstrated unique selectivity, which warrants their further study as a new means to optimize chromatographic resolution. One technique used to fabricate... Read More

• Oral Abstract

AQbD concepts were used to develop a procedure for quantification of 7 ondansetron impurities by UHPLC-UV. Independent screening tests (G-optimal design) were run considering reversed-phase (RPC), ion-pair (IPC) and hydrophilic-interaction chromatography (HILIC). IPC presented the best performance and an optimization design was run including in-silico robustness studies by using monte... Read More

• Oral Abstract