The recently developed Potentiometric-Scanning Ion Conductance Microscopy (P-SICM), is a rising sub-class of SICM that utilizes a theta pipette that holds micro-electrodes to perform current and potentiometric measurements to produce simultaneous topographical and conductance mapping of biological and non-biological surfaces, which aid in the study of cell monolayer’s permeability. Here,... Read More

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Nanopipettes are robust probes extensively used for microscopy techniques. They have been employed in our lab previously for selective analyte extraction and to study chemical reactions in local environments through mass spectrometry. The study presented here describes development of a nanopipette-based probe for simultaneous sampling and chemical analysis by nanoelectrospray... Read More

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Secretion changes of cell which can be monitored through electrochemical measures can report on the status of cellular conditions (e.g. pathological or normal). With the development of deep learning algorithms applied in the field of biological studies, topographic or electrochemical images taken can be used to set up a robust... Read More

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Through the application of high-throughput techniques we have developed a method for rapid screening and optimization of electrochemical conditions. This technique has been shown to work for electroanalysis, electroorganic synthesis, and inorganic synthesis of nanoparticles. Using this technique large data sets can be generated and to find optimized conditions. With... Read More

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Low oral pH (<5.5) has been shown to play an important role in dental erosion. Therefore, the measurement of oral pH can be useful in preventative care, particularly in aiding the dental caregiver in determining the likeliness of future dental cavities. The measurement of oral pH has become a more... Read More

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Carbon-fiber microelectrodes are a common, bio-compatible electroanalytical tool for the quantification of sub-second neuronal signaling with excellent spatiotemporal resolution within live brain tissue as well as at single cells. In the case of studying single cell exocytotic events, amperometry is employed using disk carbon microelectrodes to create an artificial synapse.... Read More

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Nitrate is an essential nutrient to plants and is often added to agricultural lands to increase crop yields. Unfortunately over application can lead to run-off into adjacent surface water leading to algal blooms and resulting death of aquatic life. In order to facilitate appropriate application of nitrogen fertilizer,... Read More

Track(s)

• Environmental

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During the age of the COVID pandemic, it has been critically important to keep students engaged in science research while also keeping them safe from disease infection. We report here the methods that we developed as a team of a faculty member and 6 undergraduate research students that allowed... Read More

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Culturally-relevant and culturally-sustaining pedagogy encourages practitioners to move from a deficit model of viewing students as lacking skills to an asset-based model which embraces the different cultural and experiential contexts of each student's background. Data from such pedagogies has shown their effectiveness in increasing retention of minoritized students in STEM... Read More

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Electrokinetic separation of biomolecules in nanochannels (1.5) was achieved with the COC nanochannel device for all four rNMPs. The results acquired for COC nanoscale electrophoresis indicated high identification accuracy (>99%) of the rNMPs. Furthermore, we were able to separate the methylated rNMPs from their non-methylated counterparts, which will give an... Read More

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Electrochemistry is often a difficult topic of instruction for the undergraduate classroom. New technology and experiments make this topic more accessible than ever. Activities and instruments will be discussed that will get you excited to teach electrochemistry in terms of concentration and potential change. Half reactions take on new meaning... Read More

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Screen technology for “smart” devices continues to advance as researches seek to enhance display performance by reducing energy consumption and improving color characteristics. To that end, researchers are turning to organic light-emitting diodes (OLEDs) as the display materials due to higher energy saving and richer color compared to liquid crystal... Read More

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As manufacturing of nanomaterials becomes more mature, one direction of advancement will be towards the production of small nanoparticles (<10 nm) with tight size distribution (low polydispersity). Such nanomaterials are being achieved today by Pixelligent Technologies, which produces monodisperse colloidal zirconium dioxide particles with 4-6 nm spherical inorganic cores with... Read More

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Portable analytical devices are important to the development of point-of-care diagnostics and on-site safety testing. Electrogenerated chemiluminescence (ECL) is an analytical technique that combines features of both electrochemical and luminescence methods. It possesses electrochemical advantages such as ease of miniaturization and portability, along with the high sensitivities of fluorescence methods.... Read More

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Over the past decade, many publications have described the preparation of fluorescent carbon nanodots in a fashion that typically involves the thermal or photochemical treatment of organic materials in aqueous solutions. While many authors have formulaically shown the formation of UV-absorbing, blue-emitting fluorescent products by this method, there have been... Read More

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Several syntheses of photoluminescent silica nanoparticles (Si-NPs) derived from aminoalkyl alkoxysilane precursors have been reported in the past decade. Reported syntheses have become increasingly popular as the reaction conditions are environmentally friendly, low-cost, and yield durable luminescent sensors with potential use in biomedical and technological applications across many disciplines. Despite... Read More

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The value of the Henry's Law constant defines the solubility of a gas in a solution. A new method is proposed for determining the Henry's Law constant for gases which react with water. The colorimetric method utilizes acid/base indicators to monitor the reaction of the gas with the solvent. ... Read More

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Bacterial biofilm formation is a serious consequence of a number of diseases. The increasing prevalence of antibiotic-resistant bacteria strains makes understanding the fundamental processes behind this formation a critical aspect in designing new strategies for limiting biofilm growth. Existing methods to measure biofilm formation suffer from lengthy assay times (48-72... Read More

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Lateral Flow Immunoassays (LFIAs) are paper-based analytical devices based on antigen-antibody immunoreaction, which are widely used clinical tests, due to their rapidity and simple single-step assay operation [1]. In contrast to the conventional design targeting one analyte molecule, simultaneous measurement of multiple analytes is required for fast screening tests such... Read More

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High-performance affinity chromatography (HPAC) was used in a zonal elution format to screen the overall and site-selective binding strengths for several anti-diabetic drugs with human serum albumin (HSA) and modified forms of this protein. The modifications of this protein that were examined included glycation, as occurs during diabetes, and advanced... Read More

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Acrylamide, a neurotoxin that forms as a by-product of the Maillard reaction, was recently identified in several foodstuffs that are roasted or browned, such as potatoes, bread and roasted coffee beans. Formation of acrylamide in roasted coffee beans contributes to the overall human exposure to this toxin, resulting in legislation... Read More

Track(s)

• Food Science/Agriculture

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