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JAIMA (Japan Analytical Instruments Association) -ETC (Enabling Technology Consortium) - Open Innovation Platform for Analytical Solutions in Biopharma and Biotherapeutics
Tuesday, March 09, 2021: 1:30 PM - 4:05 PM
Speaker(s)
Description
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New proposals of analytical solutions for biopharma and biotherapeutics using various analytical instruments such as Raman spectroscopy, cryo–EM, 2D-LC-SFC-MS and
X-ray crystallography are presented. Throughout this workshop, we aim to reveal the importance of combination of these various analytical instruments for the requirements
from pharmaceutical practice and process.
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Additional Info
Presentations:
- Session Number: W02-01
- Tuesday, March 09, 1:30 PM - 1:50 PM
Glycosylated proteins used as biopharmaceuticals, including monoclonal antibodies (mAbs), are among the most promising candidates in the drug development pipeline. Glycosylation is a critical factor in drug product solubility, kinetics, stability, efficacy, and immunogenicity. Understanding the inherent heterogeneity of N-glycan moieties of the Fc region of mAbs is an important...
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- Session Number: W02-02
- Tuesday, March 09, 1:50 PM - 2:10 PM
In the past decade two-dimensional liquid chromatography (2D-LC) has transitioned from being a research tool in select laboratories to main stream pharmaceuticals. With the increase in sample complexity especially with the number of chiral centers, resolution of potential stereoisomers by chiral chromatography becomes challenging if not impossible. 2D-LC (RP-RP) has...
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- Session Number: W02-03
- Tuesday, March 09, 2:10 PM - 2:30 PM
Polarized Excitation-Emission Matrix (pEEM) spectroscopy offers a unique approach to the measurement of protein variance and stability in solution. pEEM is basically a 4D (λex, λem, IF, r) extension of conventional 3D EEM measurements (λex, λem, IF). The polarization element provides unique information about protein size and mobility. The big...
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- Session Number: W02-04
- Tuesday, March 09, 2:30 PM - 2:50 PM
In recent years, single particle analysis (SPA), which deduces a structure of a protein molecule from images of dispersed sample molecules embedded in ice using cryo transmission electron microscope (cryo-TEM), have been getting increased attention. Realization of low-dose imaging and compensation of sample drift including beam-induced motion by the advent...
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- Session Number: W02-05
- Tuesday, March 09, 3:05 PM - 3:25 PM
Our industry has long been late in adopting new information technologies to streamline our information needs. No place has this been more pronounced than in the laboratories themselves. This discussion will focus on brining “Next Generation” laboratory capture technologies, including wearable devices, voice, image and video capture into our laboratories....
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