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Supramolecular Electrochemistry within Nanopores
Monday, March 08, 2021: 1:30 PM - 2:05 PM
Speaker(s)
Description
Nanostructured materials have been explored as critical components to design highly sensitive and selective supramolecular electrochemical sensors. The performance improvement of these sensors is often attributed to the large surface area and the controlled permeability of the nanostructures for ions and molecules. In addition, their nanospaces can afford unique environments that enhance and/or regulate chemical recognition and electron transfer processes. In this presentation, I will introduce our efforts aiming at fundamental understanding of the effects of nanospaces on supramolecular electrochemistry. We fabricated recessed nanodisk-array electrodes by coating planar gold electrodes with thin nanoporous films derived from cylinder-forming diblock copolymers. The polymer-based films provided unique model systems for the fundamental studies owing to their high-density cylindrical nanopores with tunable homogeneous dimensions and surface chemistry. Electrochemical processes within the nanopores, which could be modulated by chemical recognition processes, were measured at the underlying electrodes. We assessed electron hopping efficiency through ferrocene moieties tethered onto the insulator-based nanopores. The electron hopping could be reversibly inhibited by the complexation of the ferrocene moieties with cyclodextrin. More interestingly, the inhibition was observed at very low cyclodextrin concentrations, suggesting the preferential partition of cyclodextrin into the hydrophobic nanopores. We also investigated the characteristics of folding-based electrochemical DNA sensors fabricated at recessed nanodisk-array electrodes. These sensors exhibited better detection sensitivity, attributable to enhanced hybridization and electron transfer processes that may result from the restricted dynamics of redox-tagged stem-loop DNA probes within the nanopores. These works revealed the utility of nanopores for designing highly-sensitive supramolecular electrochemical sensors.
Additional Info
Keywords: Please select up to 4 keywords ONLY:
Voltammetry,Nanoscience,Polymers
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