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Enhancing Chiral Separations using Superficially Porous Particles
Friday, March 12, 2021: 1:30 PM - 2:05 PM
Speaker(s)
Description
Chiral/enantiomeric separations play a vital role in academic and industrial research. Pharmaceutical, agricultural sciences, and other regulatory bodies heavily depend on chiral analyses. Enantiomeric separations have a rich history of trials tribulations and triumphs spanning more than five decades. Originally, most of the research enantiomeric separations was focused into the creation of a variety chiral stationary phases (CSPs) which could separate specific classes of compounds. However, while the breadth of chiral selectivity increased, throughput of enantiomeric separations has remained relatively unchanged, until the last five years. It was normal to wait for 5 to 40 min to chromatographically separate just two enantiomers. Superficially porous particles (SPP), also known as core shell particles, are now commonplace on high performance liquid chromatographs (HPLC). Adoption of SPPs on CSP has been slow but beneficial. Compared to fully porous particles, SPP's have better eddy diffusion parameters and improved mass transfer kinetics. These advantages make ultra-fast enantiomeric separations possible. Enantiomeric separations can now be attained at sensor acquisition speeds in less than one second, which redefines the state of the art of chiral separation technology.
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Enantiomeric Separations
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