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Deconvolution of the Individual Current-voltage Curves for Two Faradaic Reactions Electrically Coupled by a Bipolar Electrode
Monday, March 08, 2021: 8:30 AM - 6:00 PM
Speaker(s)
Description
Many electrochemical sensing applications require simultaneous detection of several analytes - such as heavy metal contaminants in drinking water or a panel of biomarkers for a disease. Bipolar electrodes (BPEs) are especially advantageous for such applications because they are wireless, allowing arrays of thousands of BPEs to be operated in parallel. To ascertain the current for BPE-based sensors one end of the BPE is utilized for an observed (sensing) reaction which is electrically coupled to a reporting reaction, providing information about the system as a whole instead of the sensing reaction alone, as is desired. We recently reported AC voltammetry at BPEs with electrochemiluminescence as the reporting reaction. In this system, the convolution of two reactions led to an appreciable amount of error in the reported signal.
To address this issue, we are developing a compensation method to improve the accuracy of BPE-based sensing platforms. We hypothesized that the current-voltage curve for each of the reactions coupled by a BPE could be distinguished by monitoring the overall impedance and modeling the system with an equivalent circuit. Preliminary results indicate that this is a reasonable path for deconvolution - two individual voltammograms were extracted from the mixed signal with their key features aligning with expectations. This approach will be expanded by characterizing several electrochemical reactions individually (in a 3-electrode cell) and coupled (at a BPE) under a series of conditions (e.g., concentration and AC frequency). The results of these trials will aid in vetting this deconvolution approach. We expect to develop computer code that will correct the signal for the sensing reaction (unknown) when given minimal known input information about the reporting reaction. This code will then be shared broadly via our research group website. We anticipate that this research will improve the accuracy of BPE-based sensors
Additional Info
Keywords: Please select up to 4 keywords ONLY:
Data Analysis and Manipulation,Fluorescence and Luminescence,Potentiometry,Voltammetry
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