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The Promise and Pitfalls of Cannabidiol
Thursday, March 11, 2021: 9:40 AM - 10:15 AM
Speaker(s)
Description
The cannabis plant contains more than 140 cannabinoids and more than 500 other compounds including flavonoids, terpenoids, polyaromatic hydrocarbons and alkaloids. Public perception of risks of cannabis use and changing legislation raised the visibility of cannabis and cannabinoids as offering unique mechanisms of action as pharmacotherapies, as well as drugs increasing euphoria and relaxation. Unfortunately, cannabis is also second only to ethanol for driving under the influence of drug cases. ∆9-tetrahydrocannabinol (THC), the primary psychomimetic cannabinoid in cannabis has a long history of medicinal use stretching back 4000 years. Although synthetic THC (dronabinol) and other analogs are approved drugs in many countries worldwide, extensive research has not achieved separation of its therapeutic effects from its psychoactivity, limiting its usefulness. Many phytocannabinoids are being considered for medications, but cannabidiol (CBD) is the cannabinoid of most interest. CBD is non-intoxicating, but the well-designed clinical studies documenting the drug’s efficacy are not available, except for FDA-approved Epidiolex®, a purified CBD extract for treatment of infantile refractory epileptic syndromes. CBD showed potential in in vitro and preclinical studies as an anxiolytic, antipsychotic, anti-inflammatory, anti-spasticity, analgesic, and anti-cancer drug. In animals at higher doses than recommended for humans, CBD’s adverse effects included developmental toxicity, embryo-fetal mortality, central nervous system inhibition and neurotoxicity, hepatocellular injuries, spermatogenesis reduction, organ weight alterations, male reproductive system alterations, and hypotension. CBD induced drug-drug interactions, hepatic abnormalities, diarrhea, fatigue, vomiting, and somnolence. The pharmacology of this interesting cannabinoid, its potential therapeutic applications and adverse effects, drug-drug interactions and pharmacokinetics will be presented.
Track(s)
Additional Info
Keywords: Please select up to 4 keywords ONLY:
Clinical/Toxicology,Natural Products,CBD
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