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Vibrational Spectroscopy and PAT: What's Changed in 30 Years?
Thursday, March 11, 2021: 9:15 AM - 9:50 AM
Speaker(s)
Description
This lecture covers applications of Process Analytical Chemistry (PAT) using vibrational spectroscopy in both industry and academia, with applications ranging from bulk chemicals manufacture to the synthesis of the anti-malarial drug Artemisinin. First we consider the bulk production of titanium dioxide. This work, dating from 1993, is one of the earliest examples of closed-loop Raman process control, requiring continuous analysis of a hot, heterogeneous, abrasive and pervasive powder. We discuss the issues encountered in obtaining reliable spectra, in particular the engineering challenges of coupling spectrometer to sample in a hostile environment. Access to pre-commercial Raman instrumentation and development of a robust sampling interface were key to the success of this project, which yielded significant improvements in product quality and throughput [Clegg et al, Appl. Spectrosc.2001, 55, 1138-1150]. We also consider how a modern day installation might differ. Our second example considers photochemistry, potentially a very powerful tool for manufacturing chemicals. Indeed, more than a century ago, Ciamician, presented a very powerful vision of Green Chemistry and where photochemistry could lead us [Science 1912, 36, 385-394]. By comparison, the penetration of photochemistry into chemical manufacture remains relatively modest because of a range of issues, mostly centred on the problems of carrying out large-scale photochemical reactions efficiently and safely. PAT is key to addressing some of the challenges of making photochemical processes greener and more energy efficient as well as producing more widely accessible methodologies. This lecture will provide examples of using infrared and Raman spectroscopy to monitor reactions which are part of a programme aimed at generating a generic approach for the linking and scaling up multi-step processes in the context of photo, electro and thermal chemistry.
Additional Info
Keywords: Please select up to 4 keywords ONLY:
Process Analytical Chemistry,Green Chemistry,Infrared Spectroscopy,Raman/Surface Enhanced Raman Spectroscopy
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