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Multimodal Nanoscale Electrochemistry for Cytokine Diagnostics
Wednesday, March 10, 2021: 9:50 AM - 10:25 AM
Speaker(s)
Description
Two specially constructed architectures – nanopore electrode arrays (NEAs) and closed bipolar electrochemical cells (CBEs) offer unique opportunities for electrochemical bioanalysis. CBE devices can be used to couple analytically-useful redox processes occurring in one micro- or nanofluidic cell - the analytical cell - to a variety of optical readouts (fluorescence, absorption, surface plasmon resonance shifts) occurring in a remote cell – the reporter cell. The physical separation of the recognition and readout functions offers operating attributes not available in more traditional electrochemical strategies and permits a great deal of design flexibility in choosing the optical readout - fluorescence, absorption, surface plasmon resonance shifts have all been demonstrated in our lab. NEAs - which are composed of parallel nanopore arrays with multiple embedded electrodes (MIM structures) that exhibit the intrinsic properties of single nanopores, e.g. confinement, surface-induced ion transport, and enhanced signal levels by redox cycling, but in a massively parallel format - offer a particularly attractive option for the analytical cell, especially because they support high efficiency redox cycling, which leads to substantial signal amplification. Applications of these optical reporter strategies for point-of-use, multiplex determinations various cytokines, including IL-6 and TNF, will be described.
Additional Info
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Nanoscience
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