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Pharmaceutical and Biopharmaceutical Applications of Compact HPLC
Tuesday, March 09, 2021: 10:30 AM - 11:05 AM
Speaker(s)
Description
The ability to obtain data rich information of a chemical process at near real-time speeds is critical to fully understand and control a given procedure. The gold standard in measuring all components involved in a complex process is chromatography. Traditional chromatographic approaches require tedious steps such as manual sampling, sample quench and/or dilution, and potential lengthy LC runtimes. Ultimately these steps limit the frequency of analysis and result in low data rates that may constrain full process understanding. Recent advancements have been made in automating high-throughput and unattended sample probing and preparation. However, one downside to the current platform capabilities is the footprint of the LC used in conjunction with the online setups. As such AbbVie ARD, in conjunction with the Enabling Technologies Consortium (ETC), has invested in new, compact LCs which are approximately the size of a shoebox. The new compact design allows for a LC to be placed in a hood rather than near it, which not only clears space in the lab, but allows for shorter sampling distances and improved analytical outputs. Additionally, the compact LC requires a very small fraction of the mobile phase used with traditional LC leading to a safer and greener option. Finally, the compact LC is a more affordable chromatograph and is front-end agnostic. As such, it has offered improved means to couple automation in analytical R&D with online LC. Several examples will be presented that demonstrate the use of compact LC with automated systems (e.g. microfluidic sampling devices, automated forced degradation systems, and tablet processing robots), essentially furthering their scope to create complete “sample in – data out” systems.
Additional Info
Keywords: Please select up to 4 keywords ONLY:
Biopharmaceutical,Capillary LC,Instrumentation,Process Analytical Chemistry
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