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Method Development and Optimization in Liquid Chromatography
Friday, March 12, 2021: 9:50 AM - 10:25 AM
Speaker(s)
Description
Analyses by liquid chromatography (LC) critically depend on good methods and developing these is the hallmark of good chromatographers. For at least 40 years – or slightly shorter for youngish researchers [1] – the systematic development of LC methods has been an active area of research. Such efforts may be based on a minimum number of experiments or on an in silico approach aimed at quantitative structure-retention relationships [2]. While the ingredients of an experiment-based approach have barely changed, the practical application of such strategies has changed enormously. Among the progress made are much more-controlled, and consequently more-precise scanning experiments, much broader availability an applicability of highly informative detectors (especially mass spectrometers), automatic peak-tracking algorithms, even for extremely complex chromatograms, adequate retention models for a variety of LC modes (not just reversed-phase, but also HILIC, ion-exchange, etc.), smart optimization algorithms (including application of techniques from the artificial-intelligence domain), and very powerful computers and programming platforms. All this progress now allows systematic, computer-based development and optimization of highly complex analysis, such as comprehensive two-dimensional LC (LC×LC), leading to enormous time savings and lowering the threshold for applying LC×LC in practice. [1] P.R.Haddad et al., J.Chromatogr.A 282 (1983) 71-81 [2] Y.Wen, …, P.R.Haddad, Electrophoresis 40 (2019) 2415-2419
Additional Info
Keywords: Please select up to 4 keywords ONLY:
Data Analysis and Manipulation,Polymers
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