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Intraoperative Molecular Analysis In Vivo using the MasSpec Pen Technology
Monday, March 08, 2021: 2:05 PM - 2:40 PM
Speaker(s)
Description
New technologies that enable intraoperative tissue analysis are critically needed to guide surgical procedures and improve patient outcomes. In my presentation, I will describe the clinical translation and intraoperative use of the MasSpec Pen technology for direct molecular analysis of in vivo and freshly excised tissues in the operating room. Several instrumental and device improvements were made to facilitate use in the operating room. For example, a “dual-path” MasSpec Pen interface was designed and programmed with two parallel systems that allowed simultaneous of two pens. An LED system was incorporated within the MasSpec Pen interface to announce data acquisition status during surgery, as well as audio feedback. The MasSpec Pen was used by surgeons and surgical staff during 100 surgeries over a 12-month period, allowing rapid detection of rich mass spectral profiles from 715 in vivo and ex vivo analyses performed on tissues during parathyroidectomies, thyroidectomies, breast, and pancreatic neoplasia surgeries. The MasSpec Pen enabled gentle extraction and sensitive detection of various molecular species including small metabolites and lipids using a droplet of sterile water without causing tissue damage. Interestingly, blood-related ions as well as exogenous compounds including anesthetics used in the surgical procedures were also detected intraoperatively. Notably, effective molecular analysis was achieved while no limitations to sequential histologic tissue analysis were identified and no device-related complications were reported for any of the patients. Collectively, the results obtained in this study show that the MasSpec Pen system can be successfully incorporated into the operating room, allowing direct detection of rich molecular profiles from tissues with a seconds-long turnaround time that could be transformative to inform surgical and clinical decisions without major disruptions to clinical and tissue analysis workflows.
Additional Info
Keywords: Please select up to 4 keywords ONLY:
Biomedical,Data Analysis and Manipulation,Instrumentation,Ionization Techniques,Clinical Analysis,Statistics
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