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Electrochemical Multi-Analyte Point-of-Care Perspiration Sensors using On Chip Three-dimensional Graphene Electrodes
Monday, March 08, 2021: 9:30 AM - 9:50 AM
Speaker(s)
Description
A multianalyte sensing device using exclusively a laser induced graphene (LIG)-based planar electrode system was developed for perspiration analysis. LIG provides a 3D scaffold of graphene and can be manufactured directly in form of electrodes easier than any other carbon electrode, also on large scale. These outstanding properties make LIG a predestined material for the affordable mass production of wearable point-of-care-sensors and has the potential to outcompete standard screen-printed electrodes. We demonstrated that LIG allows the straightforward combination of three electrochemical sensing strategies (voltammetry, potentiometry, impedance) in a multianalyte sweat analysis system. A potentiometric potassium ion-selective electrode in combination with an electrodeposited Ag/AgCl reference electrode (RE) enabled the detection of potassium ions in the entire physiologically relevant range (1 mM to 500 mM) with a fast response time, unaffected by the presence of main interfering ions like sodium and various sweat collecting materials. A kidney-shaped interdigitated LIG electrode enabled the determination of the overall electrolyte concentration by electrochemical impedance spectroscopy at a fixed frequency. Enzyme-based strategies with amperometric detection share the common RE and were realized with Prussian blue as electron mediator and a biocompatible chitosan layer for enzyme immobilization and protection of the electrode. Using glucose and lactate oxidases, lower limits of detection of 13.7 ± 0.5 µM for glucose and 28 ± 3 µM for lactate were obtained, respectively. The sensor showed a good performance at different pH, with sweat collecting tissues, on a model skin system and furthermore in synthetic sweat as well as in artificial tear fluid. Response time for each analytical cycle totals 75 seconds, and hence allows a quasi-continuous and simultaneous monitoring of all analytes.
Additional Info
Keywords: Please select up to 4 keywords ONLY:
Integrated Sensor Systems,Potentiometry,Voltammetry,Clinical Analysis
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