Samplix  

Herlev,  Danmark 
Denmark
  • Booth: 1447

Visit our booth and attend our CoLab talk Friday 18th at 10 AM in CoLab 2:

Xdrop™ - Targeted Sequencing enabled into the Dark and Unknown 

Speaker: Dr. Peter Mouritzen

The Xdrop technology, a novel automated microfluidics-based targeted enrichment system, enables fast targeted enrichment while maintaining the quality of the DNA and thus makes it possible to avoid the artefacts introduced with other enrichment technologies

Brands: Xdrop™ - a novel automated microfluidics-based targeted enrichment system. Ideal for structural variations, gap closing, CRISPR verification sequencing, variable viruses or bacteria, pseudogenes, etc.


 Videos

Xdrop - how it works!

 Press Releases

  • Samplix Launches Xdrop™ – Providing PCR-free Target Enrichment of Single Molecules
    Sep 2nd, 2019

    Today, Samplix announced the commercial launch of its Xdrop™ sample preparation products for PCR-free target enrichment yet maintaining PCR-level specificity.

    Xdrop™ enables single molecule resolution and bias free enrichment of genomic regions longer than 100 kb from as little as 1 ng genomic DNA. Xdrop™ fits seamlessly with any sequencing platform and works equally well with both short-read and long-read sequencing systems.

    "We are excited to launch our Xdrop™ sample preparation products that allow our customers to discover the true biological representation which we all acknowledge is challenging," said CEO Lars Kongsbak. "To put it simply, Samplix allows customers to get more out of their samples by eliminating
    today’s many shortcomings in sample preparation such as bias and lack of representation, which jeopardize the downstream sequencing".

    The Xdrop™ system builds on Samplix’ proprietary technologies to partition single molecules in microfluidics cartridges that are simple to use. The product offering comprises an Xdrop™ instrument for cartridge control, different microfluidics cartridges and several molecular biology
    consumables optimized to work with the microfluidics cartridges.

    Samplix’ sample preparation is unique as it provides for PCR-free enrichment of large single molecules spanning entire genomic regions. The long-range information may comprise phasing, structural variants, repetitive sequences etc. Furthermore, as very little knowledge about the target sequence is required, the Xdrop™ enrichment may equally be applied to investigate unchartered genomic regions.

    Samplix is accepting purchase orders for the Xdrop™ instrument at an initial price of USD38,000 and shipments will commence immediately.

    For more information, please visit www.samplix.com.

    ABOUT SAMPLIX
    Samplix offers proprietary products for PCR-free targeted single molecule enrichment of genomic regions. Samplix’ technologies are based on advanced microfluidics, which in a simple work process, partitions millions of molecules in droplets thereby enabling high quality non-biased targeted enrichment of large fragments (>100 kb) for subsequent sequencing.


 Products

  • Xdrop
    Xdrop™ - a novel automated microfluidics-based targeted enrichment system. Ideal for structural variations, gap closing, CRISPR verification sequencing, variable viruses or bacteria, pseudogenes, etc....

  • The Xdrop™ technology, a novel automated microfluidics-based targeted enrichment system, enables fast targeted enrichment while maintaining the quality of the DNA and thus makes it possible to avoid PCR errors and bias previously introduced in enrichment. Apart from the Xdrop™ reagents, just 0.2-10 ng of input DNA and two adjacent 20-25 bp primers are used for the enrichment of a chromosomal region and it is therefore fast and easy to set up for a new region. The primers can be located in the central part of the target region or flanking an unknown region which allows for unknown sequences to be enriched together with the target region. This feature makes the Xdrop™ system relevant for regions with structural variations, gap closing, CRISPR verification sequencing, variable viruses or bacteria, pseudogenes, etc. 


    At our CoLab talk Friday 10 AM in CoLab 2,  we present the Xdrop™ system being employed to sequence integrated viruses and their surrounding unknown chromosomal sequence, sequence long GC repeats, and we show phasing of mutations from sub-nanograms of DNA. Regions of 40-70 kb are enriched and sequenced using Illumina, PacBio, and Oxford Nanopore sequencing at high coverage. We also show that the Xdrop™ system can be used for general, unbiased isothermal amplification of small amounts of samples of DNA for any type of downstream sequencing.

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