Phoenix S&T develops and sells performance-enhancing devices for proteomics and biomarker R&D. New in 2022: 1) We introduce two clog-resistant spray emitters: the laser-pulled chemically etched fused silica nano and microspray emitters and the nozn-clogging, fitting-less plastic nozzle emitters. 2) Source upgrade for the Bruker Apollo source for nanoLC-MS and off-line nanospray. Our tried and true widely adopted column heaters continue to dramatically improve scheduled MRM, lower back pressure, substantially reduce carry-over, and improve resolution, and are programmable for rinsing and analysis. They heat columns of different design, trap, filter, transfer lines, etc. The Nimbus and pneu-Nimbus automated dual-column sources double the productivity of nanoLC-MS with minimal financial and personnel investments, enable semi-automated method development. NanoFlex or Sciex Nanospray sources can be upgraded to dual-column operations.