The TrueMass CDMS (Charge detection mass spectrometry) technology brings researchers a step closer to obtaining the true mass of previously unattainable large biomolecules, with the ultimate goal of accelerating scientific discovery and shortening time to market for new innovations, such as therapeutics and advanced materials. As the first commercial CDMS instrument on the market, the TrueMass system has turned the mass analysis of ultra-high molecular weight particles into a reality. Until now, the applications of CDMS technology have been limited due to the trade-off between resolution and throughput. The next-generation mass analyser geometry and advanced electronics speed up ion trap CDMS, making this technology widely accessible for a range of research and industrial applications.