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March 8 - 12, 2021

ALL TIMES SCHEDULED ARE EASTERN STANDARD TIME (EST)


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Virtual Pittcon 2021

Emerging Compact/Portable LC Technologies and Applications

  • Session Number: L32-06
Wednesday, March 10, 2021: 2:50 PM - 3:10 PM

Speaker(s)

Co-Author
Elisabeth Gates
Axcend
Co-Author
Gregory Ward
Axcend
Co-Author
H. Dennis Tolley
Brigham Young University
Co-Author
Leena Patil
Brigham Young University
Co-Author
Luke Tolley
Axcend LLC
Author
Milton Lee
Axcend
Co-Author
Paul Farnsworth
Brigham Young University
Co-Author
Paul Peaden
Axcend LLC
Co-Author
Raymond West
Axcend
Co-Author
Xiaofeng Xie
Axcend Corporation

Description

The analytical instrument industry continues to follow the life-changing trend set by the electronics industry of significantly reducing the size of components and products. Reduction in size generally allows greater mobility, simpler operation, and lower cost, which in turn leads to more widespread use. Although LC has been slow to move in this direction compared to spectrophotometry and GC, for example, new developments in materials and hardware components have accelerated efforts to develop compact LC. In the last few years, truly portable gradient LC has become commercially available, offering small high pressure pumps that can deliver microliter to nanoliter/min mobile phase flow rates, fittings and transfer lines that minimize dead volumes to preserve chromatographic efficiency, and multiple detector options including single wavelength on-column UV-absorption with LED light sources or multi-wavelength DAD, fluorescence and, of course, MS. Small diameter (< 0.250 mm i.d.) packed capillary columns are pre-mounted in temperature-controlled, easy-to-connect cartridges that literally take less than minute to install/exchange. These columns can be custom prepared for on-column detection, or a miniaturized detector z-cell can be utilized for direct coupling to capillary columns purchased from a variety of column manufacturers. Examples of applications that are particularly well suited for portable LC analysis include point detection of hazardous chemicals, point-of-care clinical assays, chemical process monitoring, first responder operations such as detection of abuse drugs, chemical reaction optimization, and tracking both agricultural growth maturity and persistence of agrichemical applications. The extremely low mobile phase flow rates characteristic of portable capillary LC minimize the cost and bother of purchasing and disposing of solvents, and clearly position the technique in the elite class of “green analytical chemistry.”

Additional Info

Keywords: Please select up to 4 keywords ONLY:
Capillary LC,Environmental - Water,Instrumentation,Green Chemistry



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