Pittcon 2022 | March 5 - 9, 2022
Georgia World Congress Center
Atlanta, Georgia, USA


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Target Screening for 1,4-dioxane and Simultaneous Non-Target Characterization of Consumer Products with GC-MS

  • Room: B403
  • Session Number: G19-03
Sunday, March 06, 2022: 2:10 PM - 2:30 PM


Elizabeth Humston-Fulmer
Application Chemist
LECO Corporation
Joseph Binkley
Applications Manager Separation Science
LECO Corporation
Lorne Fell
Product Manager Separation Science
LECO Corporation


With a changing regulatory landscape, there are growing needs for analytical methods to screen for 1,4-dioxane in a range of sample types. Dioxane, a potential carcinogen, is a possible by-product or impurity that can be observed in some personal care products and various household cleaning supplies. Its presence in these consumer products is a concern for both the direct exposure to the consumer and also as an introduction path to the environment through wastewater. Dioxane is soluble in water and does not readily biodegrade, so can be a challenge for water treatment facilities and may impact drinking water sources. For these reasons, there is interest in screening for dioxane in consumer products and developing regulation to reduce the allowed levels. Gas chromatography with mass spectrometry (GC-MS) is well-suited to address these analytical tasks. With a wide range of potential samples types, GC is important for separating dioxane from other components in the complex samples that may vary between sample types. MS provides both selectivity and sensitivity and can help distinguish dioxane from other unknown matrix interferences, leading to reliable identification and quantification. While dioxane may be the primary target, GC-MS also uncovers additional information in these samples with the non-target data that is acquired. For example, these methods can also provide information for fragrance analytes in the personal care products. Targeted screening of dioxane and non-targeted characterization for a variety of samples are demonstrated in this work.


Additional Info

Category: Please choose one (1):
Gas Chromatography/Mass Spectrometry

Keywords: Please select up to 4 keywords ONLY:
Cosmetic,Method Development,Safety

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